yes kalixicon can cause diarrhoea. Clarihtromycin (Kalixicon) can cause diarrhoea by many mechanisms. It is a pro-kinetic drug, in the sense increases the gut mobility. This particular effect/side effect has been skillfully used in the setting of sluggish bowels in the intensive care settings and in diabetic gastro paresis.
Clarithromycin can also cause diarrhoea by eliminating the normal bacteria for a health gut and this in turn leads to superinfection of harmful bacteria.
generally extended penicillins, compound penicillins, tetracyclines and the clarithromycin group (macrolides) can all lead to diarrhoea.