What are the effects of creatinine levels on a person who has high muscle mass as a result of years of heavy weight training and who consumes a high protein diet and uses creatine based supplements. In this situation is a blood test of creatinine levels an accurate indication of kidney function.
Prof. Johan Rosman
Prof. Johan Rosman
Nephrologist
Perth
Only when the amount of creatine consumed and the training circumstances and the muscle mass are constant, series of creatinine can be useful.The creatinine can not be used to estimate renal function, as too many external factors that are used in the calculation (that is based on average muscle mass) are playing a role.

What can be done, and gives a far more reliable results is the 24-hour creatinine clearance, where the blood creatinine is measured and the same day exactly 24 hours of urine is collected to measure how much creatinine such an individual is urinating out.

It needs to be said that high protein diets and the use of creatine is not good for the kidneys. especially if they are damaged for whatever reason, the rate of loss of kidney function is much faster with creatine use and high protein diets.

Dr. Sanjeev Baweja
Dr. Sanjeev Baweja
Nephrologist
Lismore
Due to high consumption of creatine, which would eventually metabolise in to creatinine and high endogenous production of creatinine from high muscle mass the serum creatinine measurement to estimate kidney function would be misleading. A molecule called "cystatin C' can be measured in this circumstance and would give better estimation of kidney filtration rate. If a more accurate estimation is required, like for kidney donation purpose, a special nuclear medicine test would be most useful.

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