When you must not take it
There are some people who should not take Perindopril.
Please read the lists below. If you think any of these situations apply to you, or you have any questions, please consult your doctor or pharmacist.
Do not take this medicine if you have had an allergic reaction to perindopril or any of the ingredients listed at the end of this leaflet.
Symptoms of an allergic reaction may include: shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue, throat or other parts of the body; muscle pain or tenderness or joint pain or rash, itching or hives on the skin.
Do not take this medicine if you are pregnant. Perindopril may affect your developing baby if you take it during pregnancy.
Do not take this medicine if you are breast-feeding. It is not known if perindopril passes into human breast milk.
Do not take this medicine if you undergo renal dialysis using polyacrylonitrile membranes.
Do not take this medicine if you have renal artery stenosis (a problem with the blood vessels to one or both kidneys).
Do not take this medicine if you have experienced swelling of the face, tongue, lips or throat, either suddenly or in response to another medicine in the past (a rare allergic condition known as angio-oedema).
Do not take this medicine if you are intolerant or allergic to lactose. This medicine contains lactose.
Do not take this medicine after the expiry date (EXP) printed on the pack. If you take this medicine after the expiry date has passed, it may not work as well.
Do not take this medicine if the packaging is torn, shows signs of tampering or if it does not look quite right.
If it has expired or is damaged, return it to your pharmacist for disposal.
Before you start to take it
Tell your doctor if:
- You have allergies to:
- any other medicines
- any other substances, such as foods, preservatives or dyes.
- You have or have had any medical conditions, especially the following:
- Kidney disease
- Liver disease
- Heart disease
- High or low levels of potassium, sodium or other problems with salt balance
- You are undergoing, or have had an allergic reaction during previous, low-density lipoprotein (LDL) apheresis, a technique where LDL is 'filtered' out of a patient's blood, using dextran sulphate.
- You have recently suffered from diarrhoea or vomiting.
- You are undergoing de-sensitisation treatment or have had an allergic reaction during previous desensitization treatment (e.g. treatments using bee, wasp or ant venom).
- You are to undergo anaesthesia and/or surgery
- You plan to become pregnant or breast-feed.
If you have not told your doctor about any of the above, tell them before you start taking this medicine.
Taking other medicines
Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. Some medicines and perindopril may interfere with each other. These include:
- Some antibiotic drugs.
- Some anti-inflammatory drugs.
- Lithium medications (used to treat mood swings and some types of depression).
- Potassium-sparing diuretics, sources of potassium, like potassium tablet and salt substitutes containing potassium.
- Some medications used to treat high blood pressure (including diuretics (sometimes called "fluid" or "water" tablets) a fast or irregular heartbeat, and other heart conditions (It is especially important to tell your doctor when taking blood pressure, water and/or heart tablets together with anti-inflammatory drugs and perindopril)
- Medicines used to treat diabetes (tablets and insulin)
- Gold injections used for treating arthritis
- Medicines which make your heart beat faster or your blood pressure go up, such as decongestants (in cold remedies) or adrenaline.
These medicines may be affected by perindopril or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines.
Your doctor and pharmacist can tell you if you are taking any of these medicines. They may also have more information on medicines to be careful with or avoid while taking perindopril.
Other interactions not listed above may also occur.
Follow all directions given to you by your doctor or pharmacist carefully. They may be different to the information in this leaflet.
If you do not understand any written instructions, ask your doctor or pharmacist for help.
How much to take
Your doctor or pharmacist will tell you how many tablets you will need to take. This depends on your condition and whether or not you are taking any other medicines.
The usual dose of perindopril:
- For high blood pressure is up to 8 mg once daily.
- For heart failure is up to 4 mg once daily.
- For coronary artery disease is up to 8 mg once daily.
Elderly people can generally use perindopril safely. However, some older people have reduced kidney function- in which case the starting dose of perindopril should be 2 mg once daily. A less frequent dose may be used with serious kidney failure.
How to take it
Swallow your tablet(s) with a glass of water.
When to take it
Take it at about the same time each day, preferably in the morning before breakfast. Taking your medicine at the same time each day will have the best effect. It will also help you remember when to take it.
How long to take it for
Perindopril can help to control your blood pressure or heart failure, but cannot cure these conditions. Perindopril treatment is usually for life – so you should keep taking your medicine for as long as your doctor tells you.
Make sure you have enough to last over weekends and holidays.
If you forget to take it
If your next planned dose is less than 6 hours away, just leave out the dose that you missed. Take the next dose at the usual time and continue as normal.
If your next dose is more than 6 hours away, take the dose you have missed as soon as you realise. Then take the next dose at the usual time and continue as normal.
Do not take a double dose to make up for the dose that you missed. This may increase the chance of you getting an unwanted side effect.
If you are not sure what to do, ask your doctor or pharmacist.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints.
If you take too much (overdose)
Immediately telephone your doctor or the Poisons Information Centre (Tel: 13 11 26 for Australia) for advice, or go to the Accident and Emergency Department at the nearest hospital, if you think that you or anyone else may have taken too much perindopril.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
If you take too much your blood pressure may fall (also known as hypotension).
Things you must do
Tell any other doctors, dentists, and pharmacists who are treating you that you are taking perindopril.
Tell your doctor immediately if you become pregnant.
If you are about to have any blood tests, tell your doctor that you are taking this medicine.
Go to your doctor regularly for a check-up. Your doctor may occasionally do tests to make sure the medicine is working and to prevent side effects.
Things you must not do
Do not give this medicine to anyone else, even if their symptoms seem similar to yours.
Do not take your medicine to treat any other complaints unless your doctor or pharmacist tells you to.
Do not stop taking your medicine, or change the dosage, without checking with your doctor.
Things to be careful of
Be careful while driving or operating machinery until you know how perindopril affects you.